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Some evidence indicates that combining corticosteroids with acyclovir (Zovirax) will decrease the duration of zoster-associated pain.1–3 However, few studies were described, and the effectiveness of acyclovir and corticosteroids in patients with severe Acute Myeloid Leukemia is unknown. Given that these two drugs are commonly prescribed and often have multiple adverse effects, it is critical that we evaluate the efficacy of combining corticosteroids with acyclovir in the management of acute myeloid leukaemia. The current evidence suggests that combining corticosteroids with acyclovir can reduce the duration of acute myeloid leukaemia. Although other combinations, such as combining dexamethasone and acyclovir,4 may also offer benefits in acute myeloid leukaemia, we do not recommend combining corticosteroids with acyclovir for managing patients with acute myeloid leukaemia in a single study. Further study is needed to identify effective combinations of medications with acyclovir and corticosteroids to achieve the desired benefits in patients with acute myeloid leukaemia. We believe that combining corticosteroid with acyclovir is important because the combined treatment may have a greater benefit in patients with severe Acute Myeloid Leukaemia. We suggest that Acetylcysteine be taken concurrently with corticosteroids to enhance disease-modifying effects of corticosteroids and also for the prevention of adverse events such as anemia. Although studies are continuing to study this combination, our research team and the Institute of Child Health Research of the University Hospital, Krakow, are currently examining the possibility of initiating studies on the combination of corticosteroids with acyclovir to prevent acute myeloid leukaemia. The relationship between corticosteroids and severe Acute Myeloid Leukaemia Patients with acute myeloid leukaemia often experience pain that resembles the acute illness in this syndrome. Acute myeloid leukaemia is a chronic immune-mediated disease that causes a wide range of symptoms and signs. These symptoms may include fatigue, increased heart rate, and changes in blood pressure.1–3 Patients with severe myeloid leukaemia, however, are more likely to have a prolonged duration of the acute infection.3 Because acute myeloid leukaemia is associated with more inflammatory cells and is characterized by decreased white blood cell counts,2,5 it is common and difficult to predict the course of this disease. In addition to the inflammatory cells Similar articles: